Mohamed Ahmed, MD, Ph.D
Professor, Chief
Department:
MD-PEDS-NEONATOLOGY
Business Phone:
(352) 273-8688
Business Email:
mohamed.ahmed1@ufl.edu
About Mohamed Ahmed
Dr. Ahmed is Professor, Department of Pediatrics, Division of Neonatology; he received his Medical Doctorate, University of Suez Canal, Egypt. Dr. Ahmed completed his Pediatrics Residency at university of Chapel Hill (UNC), Chapel Hill, NC. Postdoctoral Fellow in Medical Genetics & Neonatology, at Duke Medical Center, Durham, NC. Dr. Ahmed has received during his career several honors and awards. He Chairs and is involved on National and International Committees. Dr. Ahmed is active on several Society Membership, Editorial boards, journal reviewer, Service to the Community, Service to schools. Dr. Ahmed has received many appointments as Assistant Professor, Division of Neonatology, Milwaukee Children’s Hospital Milwaukee, WI, Associate Professor, and Associate Division Chief for Neonatology, Cohen children, Hofstra university, NY, Division chief of neonatology, Diamond children, University of Arizona, Tucson, AZ, and currently Prof and chief of division of neonatology, university of Florida, Gainesville, FL.
Additional Positions:
Eminent Scholar Chief in Pediatrics
2024 – current
·
Board Certifications
-
General PediatricsAmerican Board of Pediatrics
-
Neonatal – Perinatal MedicineAmerican Board of Pediatrics
Clinical Profile
Neonatal-Perinatal Medicine
Areas of Interest
- Bronchopulmonary dysplasia
Research Profile
Neonatal pulmonary hypertension represents a major challenge for neonatologist at early stage of life. So far, neonatal outcome of this disease is not promising, due to the increase incidence of chronic lung disease which is complicated by development of BPD and pulmonary hypertension. Our society and our population are still looking for a rescue treatment for this disease who affect human being on all age groups (from neonate to elders), not just at national level, but internationally too.
We started investigating this disease many years ago, using my previous experience in oxidative stress and its impact on neonate body systems. our studies focus on both clinical and basic/transitional research. Currently, we are studying many approaches, in a trial to improve our understanding of the pathophysiology associated with progression of pulmonary hypertension in our population and find out an innovative approach, which could be though using new molecules (e.g. MIF inhibitor, ENAMPT antibody & VIP analogue), tackling different pathways and also based on neuromodulation strategy approach.
Areas of Interest
- VIP analogue and pulmonary hypertension
- eNAMPT and chorioamnionitis using small and large animal model
- eNAMPT and pulmonary hypertension
Publications
Academic Articles
2024
Extracellular Nicotinamide Phosphoribosyltransferase Is a Therapeutic Target in Experimental Necrotizing Enterocolitis.
Biomedicines.
12(5)
[DOI] 10.3390/biomedicines12050970.
[PMID] 38790933.
2023
Galantamine ameliorates hyperoxia-induced brain injury in neonatal mice.
Frontiers in neuroscience.
17
[DOI] 10.3389/fnins.2023.890015.
[PMID] 37424990.
2023
Single-Cell Profiling of Premature Neonate Airways Reveals a Continuum of Myeloid Differentiation.
American journal of respiratory cell and molecular biology.
69(6):689-697
[DOI] 10.1165/rcmb.2022-0293OC.
[PMID] 37643399.
2023
The eNAMPT/TLR4 inflammatory cascade drives the severity of intra-amniotic inflammation in pregnancy and predicts infant outcomes.
Frontiers in physiology.
14
[DOI] 10.3389/fphys.2023.1129413.
[PMID] 37415908.
2022
Neonatal testicular torsion.
African journal of paediatric surgery : AJPS.
19(1):1-4
[DOI] 10.4103/ajps.AJPS_153_20.
[PMID] 34916342.
2021
A Retrospective Review Following the Addition of Clonidine to a Neonatal Abstinence Syndrome Treatment Algorithm.
Frontiers in pediatrics.
9
[DOI] 10.3389/fped.2021.632836.
[PMID] 34164354.
2021
Coronary vasodilation mediated by T cells expressing choline acetyltransferase.
American journal of physiology. Heart and circulatory physiology.
321(5):H933-H939
[DOI] 10.1152/ajpheart.00694.2020.
[PMID] 34597185.
2021
Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb.
Pulmonary circulation.
11(4)
[DOI] 10.1177/20458940211059712.
[PMID] 34790349.
2021
Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress.
Frontiers in cardiovascular medicine.
8
[DOI] 10.3389/fcvm.2021.669975.
[PMID] 34136546.
2021
Is the Antioxidant Capacity of Stored Human Milk Preserved?
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.
16(7):564-567
[DOI] 10.1089/bfm.2020.0407.
[PMID] 33728983.
2020
CD4+ ChAT+ T Cells (ChAT T Cells) as a New Vasodilator
A107. BYSTANDERS NO MORE: INFLAMMATION, IMMUNITY AND THROMBOSIS IN PULMONARY VASCULAR AND LUNG DISEASE.
[DOI] 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2675.
2020
Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α.
American journal of respiratory cell and molecular biology.
63(1):92-103
[DOI] 10.1165/rcmb.2019-0164OC.
[PMID] 32142369.
2020
Prophylactic inhibition of NF-κB expression in microglia leads to attenuation of hypoxic ischemic injury of the immature brain.
Journal of neuroinflammation.
17(1)
[DOI] 10.1186/s12974-020-02031-9.
[PMID] 33261624.
2019
CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension
Nature Communications.
10(1)
[DOI] 10.1038/s41467-019-11500-6.
[PMID] 31391533.
2019
EC-SOD can prevent the chronic stages of pulmonary hypertension induced by hypoxia
Integrative Molecular Medicine.
6(6)
[DOI] 10.15761/imm.1000389.
2019
MIF inhibition enhances pulmonary angiogenesis and lung development in congenital diaphragmatic hernia.
Pediatric research.
85(5):711-718
[DOI] 10.1038/s41390-019-0335-6.
[PMID] 30759452.
2019
Neuromodulation as a New Strategy in Management of Pulmonary Hypertension
A105. GLORY DAYS: THE LATEST CLINICAL RESEARCH IN PAH.
[DOI] 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2519.
2019
Persistent cloaca and caudal duplication in a monovular twin, a rare case report.
International journal of surgery case reports.
60:137-140
[DOI] 10.1016/j.ijscr.2019.06.013.
[PMID] 31220683.
2018
Macrophage migration inhibitory factor (MIF) in the development and progression of pulmonary arterial hypertension.
Global cardiology science & practice.
2018(2)
[DOI] 10.21542/gcsp.2018.14.
[PMID] 30083544.
2017
A model of Periventricular Leukomalacia (PVL) in neonate mice with histopathological and neurodevelopmental outcomes mimicking human PVL in neonates.
PloS one.
12(4)
[DOI] 10.1371/journal.pone.0175438.
[PMID] 28406931.
2017
Do Pre- and Postnatal Growth Failure Increase the Severity of Bronchopulmonary Dysplasia or Pulmonary Hypertension in Preterm Infants?
Journal of the Academy of Nutrition and Dietetics.
117(9)
[DOI] 10.1016/j.jand.2017.06.239.
2017
Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors.
Frontiers in immunology.
8
[DOI] 10.3389/fimmu.2017.01673.
[PMID] 29326685.
2017
Hypoxia-induced activation of specific members of the NF-kB family and its relevance to pulmonary vascular remodeling.
The international journal of biochemistry & cell biology.
92:141-147
[DOI] 10.1016/j.biocel.2017.09.022.
[PMID] 28987523.
2017
Pathophysiology of periventricular leukomalacia: What we learned from animal models.
Neural regeneration research.
12(11):1795-1796
[DOI] 10.4103/1673-5374.219034.
[PMID] 29239318.
2016
A Novel Strategy for Attenuating Opioid Withdrawal in Neonates.
Journal of addiction research & therapy.
7(4)
[DOI] 10.4172/2155-6105.1000291.
[PMID] 28078167.
2016
Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase.
Nature biotechnology.
34(10):1066-1071
[DOI] 10.1038/nbt.3663.
[PMID] 27617738.
2016
Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.
Physiological reports.
4(24)
[DOI] 10.14814/phy2.13069.
[PMID] 28039410.
2015
Brain region-specific alterations in the gene expression of cytokines, immune cell markers and cholinergic system components during peripheral endotoxin-induced inflammation.
Molecular medicine (Cambridge, Mass.).
20(1):601-11
[DOI] 10.2119/molmed.2014.00147.
[PMID] 25299421.
2015
Choline acetyltransferase+ lymphocytes regulate endothelial nitric oxide synthase (MUC2P.939)
The Journal of Immunology.
194(1_Supplement):65.22-65.22
[DOI] 10.4049/jimmunol.194.supp.65.22.
2015
Differential Regulation of Pulmonary Endothelial Cell Response to Hypoxia by NF‐kB Family
The FASEB Journal.
29(S1)
[DOI] 10.1096/fasebj.29.1_supplement.662.19.
2014
Hyperoxia and Regulatory T cell (Treg) development in neonatal mice Hardik Patel1, Angela Leon Hernandez1, Mark Pezzano2 and Mohamed Ahmed1 1Neonatology Research Lab, The Feinstein Institute for Medical Research, Manhasset, NY. 2Department of Biology, The City College of NY, New York, NY (LB546)
The FASEB Journal.
28(S1)
[DOI] 10.1096/fasebj.28.1_supplement.lb546.
2014
Inhibition of Cxcr 1 and 2 Delays Preterm Delivery and Reduces Neonatal Mortality in a Mouse Model of Chorioamnionitis
European Journal of Inflammation.
12(3):447-457
[DOI] 10.1177/1721727×1401200306.
2014
Overexpression of extracellular superoxide dismutase protects against brain injury induced by chronic hypoxia.
PloS one.
9(9)
[DOI] 10.1371/journal.pone.0108168.
[PMID] 25268361.
2012
Extracellular superoxide dismutase overexpression can reverse the course of hypoxia-induced pulmonary hypertension.
Molecular medicine (Cambridge, Mass.).
18(1):38-46
[DOI] 10.2119/molmed.2011.00339.
[PMID] 22045221.
2012
Is it a safe practice to administer oxygen during uncomplicated delivery: a randomized controlled trial?
Early human development.
88(8):677-81
[DOI] 10.1016/j.earlhumdev.2012.02.007.
[PMID] 22445187.
2012
Overexpression of extracellular superoxide dismutase has a protective role against hyperoxia-induced brain injury in neonatal mice.
The FEBS journal.
279(5):871-81
[DOI] 10.1111/j.1742-4658.2012.08478.x.
[PMID] 22240000.
2012
Role of EC-SOD overexpression in preserving pulmonary angiogenesis inhibited by oxidative stress.
PloS one.
7(12)
[DOI] 10.1371/journal.pone.0051945.
[PMID] 23284826.
2012
Synergistic protection against hyperoxia-induced lung injury by neutrophils blockade and EC-SOD overexpression.
Respiratory research.
13(1)
[DOI] 10.1186/1465-9921-13-58.
[PMID] 22816678.
2011
The protective effect of overexpression of extracellular superoxide dismutase on nitric oxide bioavailability in the lung after exposure to hyperoxia stress.
Experimental lung research.
37(1):10-7
[DOI] 10.3109/01902148.2010.497893.
[PMID] 21077778.
2009
Prenatal exposure to drugs: effects on brain development and implications for policy and education
Nature Reviews Neuroscience.
10(4):303-312
[DOI] 10.1038/nrn2598.
[PMID] 19277053.
2003
Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice.
American journal of respiratory and critical care medicine.
167(3):400-5
[PMID] 12406846.
2000
Clinical and Molecular diagnosis of Nager syndrome in a preterm Infant (27 week gestation) – A case report
Genetics in Medicine.
2(1)
[DOI] 10.1097/00125817-200001000-00084.
2000
Comparative genomic hybridization studies in hydatidiform moles and choriocarcinoma: amplification of 7q21-q31 and loss of 8p12-p21 in choriocarcinoma.
Cancer genetics and cytogenetics.
116(1):10-5
[PMID] 10616525.
2000
Cytogenetics and mechanisms of spontaneous abortions: increased apoptosis and decreased cell proliferation in chromosomally abnormal villi.
Cytogenetics and cell genetics.
88(3-4):230-5
[PMID] 10828596.
2000
Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
11(12):625-33
[PMID] 11149597.
2000
Postnatal developmental delay and chromosomal abnormalities.
Clinical pediatrics.
39(4):233-5
[PMID] 10791136.
1998
Familial subepithelial corneal amyloidosis (gelatinous drop-like corneal dystrophy): exclusion of linkage to lactoferrin gene.
Molecular vision.
4
[PMID] 9873069.
1998
Unconjugated estriol as an indication for prenatal diagnosis of steroid sulfatase deficiency by in situ hybridization.
Obstetrics and gynecology.
92(4 Pt 2):687-9
[PMID] 9764665.
1997
Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF).
Genomics.
42(2):227-35
[PMID] 9192842.
Education
Pediatric residency
2001-2003
·
University of Chapel Hill
Neonatal-perinatal fellowship
1999-2001
·
Duke University, Durham, NC
Medical Genetics fellowship
1995-1998
·
Duke University, Durham, NC
MD
1981-1988
·
Medical school, Suez Canal university
Contact Details
Phones:
- Business:
- (352) 273-8688
Emails:
- Business:
- mohamed.ahmed1@ufl.edu
Addresses:
- Business Mailing:
-
600 SW ARCHER RD PO Box
GAINESVILLE, FL 32610 - Business Street:
-
PO Box 100296
1600 SW ARCHER RD
GAINESVILLE FL 32610